Septum Primum

The Common Vein Copyright 2008


The septum primum is a fibrous membrane that is characterized by its central position in the atrial septum, and its central role in shunting nutrient rich maternal blood from the right sided circulation into the left, to enable structures like the brain to receive the nutrients. imaging

Structurally it is characterized by its fibrous nature, its central position surrounded by the septum secundum, and the oval shaped defect in the its superior portion.  The defect called the foramen ovale, is the conduit for blood that is shunted from the right atrium to left atrium that occurs in the fetus. When one examines the septum primum from the left atrium, the defect is seen as “u” shaped.   Superiorly the  septum primum lies on the left atrial side of the septum and overlaps the septum secundum in the region so that it can act as a valve. (see diagram below labelled “flap valve”)

Functionally the flap valve is open to flow when right atrial pressure is higher than left, (fetal condition) and it is closed when left atrial pressure is higher (post natal condition). During fetal life the right to left shunting is essential for systemic flow of blood since the pulmonary circulation offers high resistance and thus there is little flow to the lungs and therefore little flow returning to the systemic arterial circulation.  The lungs are non functioning in the fetus and hence the arteries are constricted, and hence the high resistance.  This situation changes with the first breath of air at birth.

Diseases of the fossa ovalis are almost exclusively related to diseases of the septum primum, and include ASD of the secundum type and patent foramen ovale.

Diagnostic elements relate to these diseases and include the clinical evaluation for an atrial septal defect (systolic murmur, split fixed P2, right ventricular enlargment, and pulmonary hypertension later in life) EKG showing enlarged RV, and echocardiography that can document defects in the fossa ovalis.

Treatment is usually surgical.

Atrial Septum
01669b04 heart cardiac embryology conal septum line drawing right atrium left atrium left ventricle right ventricle interatrial septum interventricular septum atrioventricular septum crux aortic annulus aorta of the heart embryology anatomy
Davidoff drawing Davidoff MD
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Flap Valve – Septum Primum                                                                                                                                       This diagram shows a coronal section of the atria with right atrium noted in blue on the patients right (our left) and the left atrium in red.  The septum primum or flap valve (white) is noted with inferior part attached to the inferior limbic band (green) and the superior aspect lying on the left atrial side behind the superior limbic band (also green)  Although not shown the most superior aspect of the septum primum is the foramen ovale.  When right atrial pressure is higher than LA pressure, blood will flow from right to left (fetal situation).  When LA pressure rises post natally as pulmonary arterial resistance decreases, then higher pressure in the LA causes the valve to close against the superior limbic band and eventually seal except for 30% of the population where a fixed seal does not occur.  The unsealed state is called a patent foramen ovale.                                                                                                                                          07538c06
Davidoff art copyright 2008 all rights reserved


Upper Middle and Lower Septal Regions of the Atrial SeptumThe diagram shows the three portions of the interatrial septum in a with the upper portion (purple deriving from sinus venosus tissue, the middle (grreen) the mesodermal tissue, and the lower (pink) the endocardial cushion tissue.  Image b, is an anatomical specimen that is overlaid in reference colors in c, and labelled in d.  The middle of the atrial septum is a fibrous membrane called the septum primum, and it is surrounded a rim of muscular tissue called the septum secundum.The septum primum is the middle portion of the interatrial septum and consists of the central solid portion called the septum primum (white) and a hidden foramen ovale which lies on the left atrial side of the septum secundum                                                                                                                                     .01653c11b05a04                                                                                                                                                    Davidoff art copyright 2008 all rights reserved


Septum Primum

Septum Primum                  The septum primum is a membrane like structure surrounded by a rim of muscle seen in the first image, and diagrammed in the second.heart cardiac atrial septum septum primum septum secundum sinus venosus right atrium normal anatomy coronary sinus thebesian valve Eustachian valve coronary sinus triangle of Koch atrioventricular node A-V node grosspathology                                                                                                                                               Courtesy Ashley Davidoff MD copyright 2008 all rights reserved                                              01671c.81s


Fossa Ovalis

Fossa Ovalis, Septum Primum, and Foramen Ovale The fossa ovalis is the depressed ring like structure surrounded by a rim of muscle seen in the first image, consisting of the septum primum and foramen ovale seen in the second diagram.  An anatomical specimen of a patent foramen ovale is seen in the third image characterized by its position and crescentic shape.                           01696c01.8s    01671     01670                                                                                                                        Davidoff MD copyright 2008 all rights reserved
Fused Foramen Ovale from the Left Atrial SideThe anatomical specimen shows an opened left atrium with each of the pulmonary veins entering and the left atrial appendage positioned in the upper right hand corner of the image. The septum primum is overlaid in pink, and the characteristic crescent shaped superior border is seen at about 1’oclock on the left atrial side of the septum secundum shown in green. This is an example of a fused foramen ovale.heart left atrium LA pulmonary veins septum primum atrial septum interatrial septum fossa ovalis foramen ovale septum secundum anatomy normal                                                                                        Courtesy Ashley Davidoff MD copyright 2008 all rights reserved                                               06426c01.8s
Left Atrium – Internal StructureThis anatomical specimen of the opened LA shows the MV, the atrial septum with fossa ovalis, and the laa. The LA is mostly smooth walled except trabeculated finger shaped laa, and bands of the superior limbic band (slb)that surround the fossa ovalis. The oval shaped (black hole) in the fossa is called the foramen ovale which has in this instance been stretched open – better known as a patent foramen ovale.Davidoff MD
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Imaging the Septum Primum

Fetal UltrasoundThe fetal ultrasound shows the right atrium in blue, left atrium in red, limbic band in green and the septum primum white, which is open and lies on the left atrial side.06428c03 heart cardiac atrial septum RA septum secundum superior limbic band inferior limbic band endocardial cushions ventricular septum fossa ovalis fetal echocardiogram LaA left atrium normal anatomy Courtesy Ashley DAvidoff MD copyright 2008ASD secundum

Types of ASD’sThe drawing shows the interatrial septum and the defects associated with each of the components. Image a shows a single defect in the septum primum and this is called an ASD secundum, or a secundum ASD. This is the most common ASD. The second image (b) shows an A-V canal defect in green and it is in the lower portion of the septum and is commonly associated with a cleft mitral valve. The third and least common defect is the sinus venosus defect. (purple)heart inteatrial septum ASD atrial septal defect secundum ASD primum ASD ASD of the sinus venosus type congenital Davidoff art copyright 2008 all rights reserved 01685c02.8


An atrial septal defect of the secundum type is a defect of the septum primum as shown below.


ASD Secundum Defect in the Septum PrimumThe anatomical specimen shows a delicate septum primum held up with a forceps and a hole is noted in the middle characteristic of an ASD secundum. The fosaa ovalis is a wide defect above the septum primum.heart atrial septum ASD secundum septum primum pathology Davidoff art copyright 2008 all rights reserved 01685b01c
MRI – ASD SecundumThe MRI shows a flow void due to the turbulence of flow through the ASD secundum – a defect in septum primum.01649b03 Courtesy Ashley Davidoff MD copyright 2008


Aneurysm of the Interatrial SeptumThese two axial CT images images through the heart reveal an atrial septum that bulges from the left atrium into the right atrium. The mitral valve is seen in image b, and shows no abnormality. This finding is consistent with a diagnosis of an aneurysm of the atrial septum.Courtesy Ashley Davidoff MD. 38362c01 code CVS heart cardiac LA RA atrial septum aneurysm imaging radiology CTscan 38362c02


Aneurysm of the Septum Primum in Mitral AtresiaThis is a pathologic specimen of a patient with mitral valve atresia (lime green overlay in b) in this view of the left atrium. The atrial septum shows a redundant perforated septum primum that was restrictive to the high pressure in the LA and an aneurysm resulted. (pale green overlay in b)Courtesy Ashley Davidoff MD. 06829c02 code CVS cardiac heart MV atrial septum ASD aneurysm mitral atresia LA congenital grosspathology
Aneurysm of the Septum Primum – Mitral AtresiaThis is a pathological image looking down upon the interatrial septum, showing an aneurysm of the interatrial septum in this patient with mitral atresia and a restrictve ASD. In image b, the light green overlay represents the aneurysm while to the right of the image in red is the left atrium, and to the left of the image (patients right) the tricuspid valve is overlaid in blue. The straight arrow in b reflects the LA blood trying to force its way through the restrictive ASD resulting in progressive bulging of the interatrial septum, while the curved arrow reflects the oxygenated blood that has found it’s way into the RA via a restrictiive ASD.Courtesy Ashley Davidoff MD 06827c01 code cardiac heart RA LA interatrial septum aneurysm ASD septum primum congenital grosspathology

Surgical Repair of an ASD Secundum

Mitral Valve and ASD Secundum RepairThis anatomical specimen is from an unfortunate pediatric patient who had a mitral valve replaced and an ASD secundum closed. The pink overlay in b shows a suture line opposing the borders of the ASD secundum. A prosthetic mitral valve is noted.heart mitral valve atrial septal defect secundum repair treatment surgery                                                                                                                                                                                                                Courtesy Ashley DAvidoff MD copyright 2008 all rights reserved 06704c01.8s